What is the ultimate goal in acid-base regulation?
نویسندگان
چکیده
It is common to see chapters on acid-base physiology state that the goal of acid-base regulatory mechanisms is to maintain the pH of arterial plasma and not arterial Pco(2) (Pa(CO(2))) or plasma HCO(3). A hypothetical situation in which the Pa(CO(2)) of arterial plasma is 80 mmHg and the plasma HCO(3) concentration is 48 mM is presented and analyzed to get over this misconception. As per the modified Henderson equation, the pH of arterial plasma would be 7.4; however, we explain that this may be associated with intracellular acidosis due to intracellular hypercapnia and that derangement of homeostasis is evident from the occurrence of respiratory depression and, eventually, coma in the patient described. This suggests that the ultimate goal of acid-base regulatory mechanisms is not just the maintenance of the pH of arterial plasma but the maintenance of the steady-state pH of intracellular fluid as well.
منابع مشابه
Teaching With Problems And Cases What is the ultimate goal in acid-base regulation?
Balakrishnan S, Gopalakrishnan M, Alagesan M, Prakash ES. What is the ultimate goal in acid-base regulation? Adv Physiol Educ 31: 51–54, 2007; doi:10.1152/advan.00010.2006.—It is common to see chapters on acid-base physiology state that the goal of acid-base regulatory mechanisms is to maintain the pH of arterial plasma and not arterial PCO2 (PaCO2) or plasma HCO3. A hypothetical situation in w...
متن کاملSelf-Regulation, Goal Orientation, Tolerance of Ambiguity and Autonomy as Predictors of Iranian EFL learners’ Second Language Achievement: A Structural Equation Modeling Approach
The identification of the cognitive, affective, social and even physiological factors affecting second or foreign language learning routes and rate has for long been a challenging aspiration for second language researchers. However, a recent preoccupation of the researchers in this area has been the study of the combinatorial impacts of such factors on second or foreign language learning proces...
متن کاملDIFFERENT NEURAL NETWORKS AND MODAL TREE METHOD FOR PREDICTING ULTIMATE BEARING CAPACITY OF PILES
The prediction of the ultimate bearing capacity of the pile under axial load is one of the important issues for many researches in the field of geotechnical engineering. In recent years, the use of computational intelligence techniques such as different methods of artificial neural network has been developed in terms of physical and numerical modeling aspects. In this study, a database of 100 p...
متن کاملReflection on the future of medical care: Challenges of social accountability from the viewpoints of care providers and patients
Introduction: Clearly, there are some challenges and difficultiesin fulfilling social accountability which should be identified anddealt with in order to reach the ultimate goal. The main objectiveof this study was to identify the challenges associated with socialaccountability.Methods: In this qualitative study, focus groups and in-depthsemi-structured interview were used to obtain the opinion...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Advances in physiology education
دوره 31 1 شماره
صفحات -
تاریخ انتشار 2007